Statement of Principles

concerning

HYPERTENSION
(Reasonable Hypothesis)

(No. 21 of 2022)

The Repatriation Medical Authority determines the following Statement of Principles under subsection 196B(2) of the Veterans' Entitlements Act 1986.

Dated                                           4 March 2022

Contents

1 Name

2 Commencement

3 Authority

4 Repeal

5 Application

6 Schedules

7 Kind of injury, disease or death to which this Statement of Principles relates

8 Basis for determining the factors

9 Factors that must exist

10 Relationship to service

11 Factors referring to an injury or disease covered by another Statement of Principles

Schedule 1 - Dictionary

1 Definitions

Schedule 2 - Drugs

1 Specified Drugs

1               Name

This is the Statement of Principles concerning hypertension (Reasonable Hypothesis) (No. 21 of 2022).

2               Commencement

              This instrument commences on 4 April 2022.

3               Authority

This instrument is made under subsection 196B(2) of the Veterans' Entitlements Act 1986.

4               Repeal

The Statement of Principles concerning hypertension No. 63 of 2013 (Federal Register of Legislation No. F2013L01652) made under subsections 196B(2) and (8) of the VEA is repealed.

5               Application

This instrument applies to a claim to which section 120A of the VEA or section 338 of the Military Rehabilitation and Compensation Act 2004 applies.

6               Schedules

Any item in a Schedule to this Instrument has effect according to its terms.

7               Kind of injury, disease or death to which this Statement of Principles relates

(1)          This Statement of Principles is about hypertension and death from hypertension.

Meaning of hypertension

(2)          For the purposes of this Statement of Principles, hypertension:

(a)          means persistently elevated blood pressure, where that persistent elevation in blood pressure has been diagnosed by a medical practitioner and evidenced by:

(i)            a usual clinic blood pressure reading of greater than or equal to 140 mmHg systolic or greater than or equal to 90 mmHg diastolic, or equivalent levels using ambulatory blood pressure measurement; or

(ii)         a usual home blood pressure reading of greater than or equal to 135 mmHg systolic or greater than or equal to 85 mmHg diastolic; or

(iii)       for persons aged under 18 years, a usual systolic or diastolic blood pressure reading of greater than or equal to the 95th centile for age and sex; or

(iv)        the regular administration of antihypertensive therapy to reduce blood pressure; and

(b)          excludes temporary elevations in blood pressure from conditions such as acute renal failure, neurogenic hypertension, eclampsia, pre-eclampsia, gestational hypertension and medications.

Note: equivalent levels using ambulatory blood pressure measurement is defined in the Schedule 1 - Dictionary.

(3)          While hypertension attracts ICD‑10‑AM code I10 or I15, in applying this Statement of Principles the meaning of hypertension is that given in subsection (2).

(4)          For subsection (3), a reference to an ICD-10-AM code is a reference to the code assigned to a particular kind of injury or disease in The International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification (ICD-10-AM), Tenth Edition, effective date of 1 July 2017, copyrighted by the Independent Hospital Pricing Authority, ISBN 978-1-76007-296-4.

Death from hypertension

(5)          For the purposes of this Statement of Principles, hypertension, in relation to a person, includes death from a terminal event or condition that was contributed to by the person's hypertension.

Note: terminal event is defined in the Schedule 1 - Dictionary.

8               Basis for determining the factors

The Repatriation Medical Authority is of the view that there is sound medical‑scientific evidence that indicates that hypertension and death from hypertension can be related to relevant service rendered by veterans, members of Peacekeeping Forces, or members of the Forces under the VEA, or members under the MRCA.

Note: MRCA, relevant service and VEA are defined in the Schedule 1 - Dictionary.

9               Factors that must exist

At least one of the following factors must as a minimum exist before it can be said that a reasonable hypothesis has been raised connecting hypertension or death from hypertension with the circumstances of a person's relevant service:

(1)          being overweight or obese for at least the 5 years before the clinical onset of hypertension;

Note: being overweight or obese is defined in the Schedule 1 - Dictionary.

(2)          consuming an average of at least 250 grams of alcohol per week for a continuous period of at least the 6 months before the clinical onset of hypertension;

Note: Alcohol consumption is calculated utilising the Australian Standard of 10 grams of alcohol per standard alcoholic drink.

(3)          consuming an average of at least 9 grams (150 millimoles) of salt per day for at least the 1 year before the clinical onset of hypertension;

Note: Sodium-containing medications may contribute to daily salt intake. Sodium-containing medications include the effervescent or soluble version of standard medicines, such as acetaminophen, ascorbic acid, aspirin, calcium carbonate, ibuprofen, sodium bicarbonate and zinc sulphate.

(4)          having renal artery stenosis at the time of the clinical onset of hypertension;

Note: Causes of renal artery stenosis include renal artery atherosclerotic disease and fibromuscular dysplasia.

(5)          having a solid organ, stem cell or bone marrow transplant before the clinical onset of hypertension;

(6)          having diabetes mellitus for at least the 5 years before the clinical onset of hypertension;

(7)          having chronic kidney disease at the time of the clinical onset of hypertension;

Note: chronic kidney disease is defined in the Schedule 1 - Dictionary.

(8)          having an endocrine disorder from the specified list of endocrine disorders at the time of the clinical onset of hypertension;

Note: specified list of endocrine disorders is defined in the Schedule 1 - Dictionary.

(9)          having sleep apnoea at the time of the clinical onset of hypertension;

(10)      having extrinsic compression of the renal parenchyma from a haematoma or mass at the time of the clinical onset of hypertension;

(11)      having:

(a)          an aneurysm of the renal artery; or

(b)          an arteriovenous fistula involving the blood supply of the kidney; or

(c)          an arteriovenous malformation involving the blood supply of the kidney;

before the clinical onset of hypertension;

(12)      having a clinically significant disorder of mental health as specified at the time of the clinical onset of hypertension;

Note: clinically significant disorder of mental health as specified is defined in the Schedule 1 – Dictionary.

(13)      having gout or hyperuricaemia at the time of the clinical onset of hypertension;

Note: hyperuricaemia is defined in the Schedule 1 – Dictionary.

(14)      taking a drug specified in the Schedule 2 - Drugs of this Instrument, where that drug cannot be ceased or substituted, for a continuous period of at least the 28 days before the clinical onset of hypertension;

(15)      taking a drug from the Specified List 1 of drugs at the time of the clinical onset of hypertension;

Note: Specified List 1 of drugs is defined in the Schedule 1 - Dictionary.

(16)      having glucocorticoid therapy as specified before the clinical onset of hypertension, and if the glucocorticoid therapy as specified has ceased or decreased before the clinical onset of hypertension, then that onset occurred within 30 days of cessation or reduction of therapy;

Note: glucocorticoid therapy as specified is defined in the Schedule 1 - Dictionary.

(17)      taking medroxyprogesterone acetate or megestrol acetate for a malignant disease or human immunodeficiency virus infection:

(a)          for at least 28 days before the clinical onset of hypertension; and

(b)          if treatment has ceased before the clinical onset of hypertension, then that onset occurred within 30 days of cessation;

(18)      inability to undertake any physical activity greater than 3 METs for at least the 1 year before the clinical onset of hypertension;

Note: MET is defined in the Schedule 1 - Dictionary.

(19)      being exposed to arsenic as specified before the clinical onset of hypertension;

Note: being exposed to arsenic as specified is defined in the Schedule 1 - Dictionary.

(20)      undergoing a course of therapeutic radiation for cancer, where the whole body was in the field of radiation, at least 1 year before the clinical onset of hypertension;

(21)      having received a cumulative equivalent dose of at least 0.5 sievert of ionising radiation to the whole body at least 1 year before the clinical onset of hypertension;

Note: cumulative equivalent dose is defined in the Schedule 1 - Dictionary.

(22)      inhaling, ingesting or having cutaneous contact with the phenoxy acid herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) or 2,4,5-trichlorophenoxyacetic acid (2,4,5-T): 

(a)          for a cumulative period of at least 1,000 hours within a consecutive period of 10 years, before the clinical onset of hypertension; and

(b)          where the first exposure occurred at least 5 years before the clinical onset of hypertension; and

if that exposure has ceased before the clinical onset of hypertension, then that onset occurred within 25 years of cessation;

(23)      inhaling, ingesting or having cutaneous contact with a chemical agent contaminated by 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD):

(a)          for a cumulative period of at least 1,000 hours within a consecutive period of 10 years, before the clinical onset of hypertension; and

(b)          where the first exposure occurred at least 5 years before the clinical onset of hypertension; and

if that exposure has ceased before the clinical onset of hypertension, then that onset occurred within 25 years of cessation;

Note: inhaling, ingesting or having cutaneous contact with a chemical agent contaminated by 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is defined in the Schedule 1 - Dictionary.

(24)      inhaling, ingesting or having cutaneous contact with a dioxin-like polychlorinated biphenyl:

(a)          for a cumulative period of at least 1,000 hours within a consecutive period of 10 years, before the clinical onset of hypertension; and

(b)          where the first exposure occurred at least 5 years before the clinical onset of hypertension; and

if that exposure has ceased before the clinical onset of hypertension, then that onset occurred within 25 years of cessation;

Note: inhaling, ingesting or having cutaneous contact with a dioxin-like polychlorinated biphenyl is defined in the Schedule 1 – Dictionary.

(25)      inhaling ambient, chronically polluted air as specified for at least 1 year, within the 2 years before the clinical onset of hypertension;

Note: ambient, chronically polluted air as specified is defined in the Schedule 1 – Dictionary.

(26)      being overweight or obese for at least the 5 years before the clinical worsening of hypertension;

Note: being overweight or obese is defined in the Schedule 1 - Dictionary.

(27)      consuming an average of at least 250 grams of alcohol per week for a continuous period of at least the 6 months before the clinical worsening of hypertension;

Note: Alcohol consumption is calculated utilising the Australian Standard of 10 grams of alcohol per standard alcoholic drink.

(28)      consuming an average of at least 9 grams (150 millimoles) of salt per day for at least the 1 year before the clinical worsening of hypertension;

Note: Sodium-containing medications may contribute to daily salt intake. Sodium-containing medications include the effervescent or soluble version of standard medicines, such as acetaminophen, ascorbic acid, aspirin, calcium carbonate, ibuprofen, sodium bicarbonate and zinc sulphate.

(29)      having renal artery stenosis at the time of the clinical worsening of hypertension;

Note: Causes of renal artery stenosis include renal artery atherosclerotic disease and fibromuscular dysplasia.

(30)      having a solid organ, stem cell or bone marrow transplant before the clinical worsening of hypertension;

(31)      having diabetes mellitus for at least the 5 years before the clinical worsening of hypertension;

(32)      having chronic kidney disease at the time of the clinical worsening of hypertension;

Note: chronic kidney disease is defined in the Schedule 1 - Dictionary.

(33)      having an endocrine disorder from the specified list of endocrine disorders at the time of the clinical worsening of hypertension;

Note: specified list of endocrine disorders is defined in the Schedule 1 - Dictionary.

(34)      having sleep apnoea at the time of the clinical worsening of hypertension;

(35)      having extrinsic compression of the renal parenchyma from a haematoma or mass at the time of the clinical worsening of hypertension;

(36)      having:

(a)          an aneurysm of the renal artery; or

(b)          an arteriovenous fistula involving the blood supply of the kidney; or

(c)          an arteriovenous malformation involving the blood supply of the kidney;

before the clinical worsening of hypertension;

(37)      having a clinically significant disorder of mental health as specified at the time of the clinical worsening of hypertension;

Note: clinically significant disorder of mental health as specified is defined in the Schedule 1 – Dictionary.

(38)      having gout or hyperuricaemia at the time of the clinical worsening of hypertension;

Note: hyperuricaemia is defined in the Schedule 1 – Dictionary.

(39)      taking a drug specified in the Schedule 2 - Drugs of this Instrument, where that drug cannot be ceased or substituted, for a continuous period of at least the 28 days before the clinical worsening of hypertension;

(40)      taking a drug from the Specified List 1 of drugs at the time of the clinical worsening of hypertension;

Note: Specified List 1 of drugs is defined in the Schedule 1 - Dictionary.

(41)      having glucocorticoid therapy as specified before the clinical worsening of hypertension, and if the glucocorticoid therapy as specified has ceased or decreased before the clinical worsening of hypertension, then that worsening occurred within 30 days of cessation or reduction of therapy;

Note: glucocorticoid therapy as specified is defined in the Schedule 1 - Dictionary.

(42)      taking medroxyprogesterone acetate or megestrol acetate for a malignant disease or human immunodeficiency virus infection:

(a)          for at least 28 days before the clinical worsening of hypertension; and

(b)          if treatment has ceased before the clinical worsening of hypertension, then that worsening occurred within 30 days of cessation;

(43)      inability to undertake any physical activity greater than 3 METs for at least the 1 year before the clinical worsening of hypertension;

Note: MET is defined in the Schedule 1 - Dictionary.

(44)      being exposed to arsenic as specified before the clinical worsening of hypertension;

Note: being exposed to arsenic as specified is defined in the Schedule 1 - Dictionary.

(45)      undergoing a course of therapeutic radiation for cancer, where the whole body was in the field of radiation, at least 1 year before the clinical worsening of hypertension;

(46)      having received a cumulative equivalent dose of at least 0.5 sievert of ionising radiation to the whole body at least 1 year before the clinical worsening of hypertension;

Note: cumulative equivalent dose is defined in the Schedule 1 - Dictionary.

(47)      inhaling, ingesting or having cutaneous contact with the phenoxy acid herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) or 2,4,5-trichlorophenoxyacetic acid (2,4,5-T): 

(a)          for a cumulative period of at least 1,000 hours within a consecutive period of 10 years, before the clinical worsening of hypertension; and

(b)          where the first exposure occurred at least 5 years before the clinical worsening of hypertension; and

if that exposure has ceased before the clinical worsening of hypertension, then that worsening  occurred within 25 years of cessation;

(48)      inhaling, ingesting or having cutaneous contact with a chemical agent contaminated by 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD):

(a)          for a cumulative period of at least 1,000 hours within a consecutive period of 10 years, before the clinical worsening of hypertension; and

(b)          where the first exposure occurred at least 5 years before the clinical worsening of hypertension; and

if that exposure has ceased before the clinical worsening of hypertension, then that worsening occurred within 25 years of cessation;

Note: inhaling, ingesting or having cutaneous contact with a chemical agent contaminated by 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is defined in the Schedule 1 - Dictionary.

(49)      inhaling, ingesting or having cutaneous contact with a dioxin-like polychlorinated biphenyl:

(a)          for a cumulative period of at least 1,000 hours within a consecutive period of 10 years, before the clinical worsening of hypertension; and

(b)          where the first exposure occurred at least 5 years before the clinical worsening of hypertension; and

if that exposure has ceased before the clinical worsening of hypertension, then that worsening occurred within 25 years of cessation;

Note: inhaling, ingesting or having cutaneous contact with a dioxin-like polychlorinated biphenyl is defined in the Schedule 1 – Dictionary.

(50)      inhaling ambient, chronically polluted air as specified for at least 1 year, within the 2 years before the clinical worsening of hypertension;

Note: ambient, chronically polluted air as specified is defined in the Schedule 1 – Dictionary.

(51)      inability to obtain appropriate clinical management for hypertension.

10           Relationship to service

(1)          The existence in a person of any factor referred to in section 9, must be related to the relevant service rendered by the person.

(2)          The factors set out in subsections 9(26) to 9(51) apply only to material contribution to, or aggravation of, hypertension where the person's hypertension was suffered or contracted before or during (but did not arise out of) the person's relevant service.

11           Factors referring to an injury or disease covered by another Statement of Principles

In this Statement of Principles:

(1)          if a factor referred to in section 9 applies in relation to a person; and

(2)          that factor refers to an injury or disease in respect of which a Statement of Principles has been determined under subsection 196B(2) of the VEA;

then the factors in that Statement of Principles apply in accordance with the terms of that Statement of Principles as in force from time to time.

Schedule 1 - Dictionary  

Note:               See Section 6

1               Definitions

In this instrument:

                               acromegaly means a chronic disease of adults resulting from excessive production of growth hormone after closure of the epiphyses.

                               albuminuria means an albumin to creatinine ratio of at least 3 mg/mmol.

                               ambient, chronically polluted air as specified means air with average annual concentrations of particulate matter with an aerodynamic diameter of < 2.5 µm (PM2.5) exceeding 10 µg/m3.

                               being exposed to arsenic as specified means:

(a)          consuming drinking water with an average arsenic concentration of at least 50 micrograms per litre for a cumulative period of at least 10 years; or

(b)          consuming drinking water resulting in a cumulative total arsenic exposure equivalent to having consumed drinking water containing at least 50 micrograms per litre for at least 10 years; or

(c)          having clinical evidence of chronic arsenic toxicity.

                               being overweight or obese means:

(a)          having a Body Mass Index (BMI) of 25 or greater; or

(b)          for males, having a waist circumference exceeding 94 centimetres; or

(c)          for females, having a waist circumference exceeding 80 centimetres.

Note: BMI is also defined in the Schedule 1 - Dictionary.

                               BMI means W/H2 where:

(a)          W is the person's weight in kilograms; and

(b)          H is the person's height in metres.

                               chronic kidney disease means:

(a)          having a glomerular filtration rate of less than 60 mL/min/1.73 m2 for at least 3 months; or

(b)          having albuminuria for at least 3 months; or

(c)          having kidney damage, as evidenced by renal biopsy, imaging studies, urinary sediment abnormalities or other markers of abnormal renal function; or

(d)          having had a kidney transplant.

Note: albuminuria is also defined in the Schedule 1 - Dictionary.

                               clinically significant disorder of mental health as specified means one of the following conditions, which is of sufficient severity to warrant ongoing management:

(a)          agoraphobia;

(b)          anxiety disorder;

(c)          depressive disorder;

(d)          obsessive-compulsive disorder;

(e)          panic disorder;

(f)           posttraumatic stress disorder;

(g)          social anxiety disorder; or

(h)          specific phobia.

Note 1:  Management of the condition may involve regular visits (for example, at least monthly) to a psychiatrist, counsellor or general practitioner.

Note 2: To warrant ongoing management does not require that any actual management was received or given for the condition.

                               cumulative equivalent dose means the total dose of ionising radiation received by the particular organ or tissue from external exposure, internal exposure or both, apart from normal background radiation exposure in Australia, calculated in accordance with the methodology set out in Guide to calculation of 'cumulative equivalent dose' for the purpose of applying ionising radiation factors contained in Statements of Principles determined under Part XIA of the Veterans' Entitlements Act 1986 (Cth), Australian Radiation Protection and Nuclear Safety Agency, as in force on 2 August 2017.

Note 1: Examples of circumstances that might lead to exposure to ionising radiation include being present during or subsequent to the testing or use of nuclear weapons, undergoing diagnostic or therapeutic medical procedures involving ionising radiation, and being a member of an aircrew, leading to increased levels of exposure to cosmic radiation.

Note 2: For the purpose of dose reconstruction, dose is calculated as an average over the mass of a specific tissue or organ. If a tissue is exposed to multiple sources of ionising radiation, the various dose estimates for each type of radiation must be combined.

                               equivalent glucocorticoid therapy means a glucocorticoid in the following table, at the doses specified in the table, or a therapeutically equivalent dose of another glucocorticoid:

                               equivalent inhaled glucocorticoid means:

(a)          2,000 micrograms of beclometasone;

(b)          1,600 micrograms of ciclesonide;

(c)          2,500 micrograms of fluticasone propionate;

(d)          1,000 micrograms of fluticasone furoate;

(e)          10,000 micrograms of triamcinolone; or

(f)           a therapeutically equivalent dose of another inhaled glucocorticoid.

                             equivalent levels using ambulatory blood pressure measurement means:

(a)          an average 24 hour blood pressure measurement of greater than or equal to 130 mmHg systolic or greater than or equal to 80 mmHg diastolic; or

(b)          an average daytime (awake) blood pressure measurement of greater than or equal to 135 mmHg systolic or greater than or equal to 85 mmHg diastolic; or

(c)          an average nighttime (asleep) blood pressure measurement of greater than or equal to 120 mmHg systolic or greater than or equal to 70 mmHg diastolic.

                               glucocorticoid therapy as specified means:

(a)          applying a high or very high potency topical glucocorticoid to at least 30% of total skin surface area, daily, for at least 6 months; or

(b)          inhaling at least 4,000 micrograms of budesonide, or equivalent inhaled glucocorticoid, daily, for at least 6 months; or

(c)          taking:

(i)            hydrocortisone, orally or by injection:

1. to a cumulative dose of at least 1,500 milligrams; and
2. at a minimum dose rate averaging 50 milligrams per day; or

(ii)         equivalent glucocorticoid therapy, orally or by injection; or

(d)            using a glucocorticoid concurrently with a drug, daily, for at least 4 weeks, where that drug can inhibit the activity of the metabolising enzyme cytochrome P450 3A4 by at least 30% (moderate to strong inhibition); or

(e)            using a glucocorticoid concurrently with a drug from the Specified List 2 of drugs, daily, for at least 4 weeks; or

(f)             using a clobetasol containing oral preparation, daily, for at least 4 weeks; or

(g)            using glucocorticoid containing enemas, daily, for at least 6 months.

Note: equivalent glucocorticoid therapy, equivalent inhaled glucocorticoid, high or very high potency topical glucocorticoid and Specified List 2 of drugs are also defined in the Schedule 1 – Dictionary.

                               high or very high potency topical glucocorticoid means:

(a)          betamethasone dipropionate 0.05%;

(b)          betamethasone valerate 0.1%;

(c)          clobetasol proprionate 0.05%;

(d)          diflucortolone valerate 0.1%;

(e)          fluocinolone acetonide 0.025%;

(f)           methylprednisolone 0.1%;

(g)          mometasone 0.1%;

(h)          triamcinolone acetonide 0.5%; or

(i)            another topical glucocorticoid of equivalent potency.

                               hyperparathyroidism means an excess level of parathyroid hormone.

                             hypertension—see subsection 7(2).

                               hyperuricaemia means having a serum urate level persistently greater than 0.40 millimoles per litre.

                               inhaling, ingesting or having cutaneous contact with a chemical agent contaminated by 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) means any of the following:

(a)          decanting or spraying;

(b)          cleaning or maintaining equipment used to apply;

(c)          being sprayed with;

(d)          handling or sawing timber treated with;

(e)          being in an environment shrouded in dust from timber treated with; or

(f)           using cutting oils contaminated with;

                               one of the following chemicals:

(i)            2,4,5-trichlorophenoxyacetic acid;

(ii)         2,4,5-trichlorophenoxypropionic acid;

(iii)       2,4,5-trichlorophenol;

(iv)        2-(2,4,5-trichlorophenoxy)-ethyl 2,2-dichloropropionate;

(v)          o,o-dimethyl-o-(2,4,5-trichlorophenyl)-phosphorothioate;

(vi)        pentachlorophenol;

(vii)     2,3,4,6-tetrachlorophenol;

(viii)   2,4,6-trichlorophenol;

(ix)        1,3,5-trichloro-2-(4-nitrophenoxy)benzene;

(x)          2,4-dichloro-1-(4-nitrophenoxy)benzene; or

(xi)        2,4-dichloro-1-(3-methoxy-4-nitrophenoxy)-benzene.

                               inhaling, ingesting or having cutaneous contact with a dioxin-like polychlorinated biphenyl means any of the following:

(a)          applying, using or removing cutting oils containing a dioxin-like polychlorinated biphenyl;

(b)          applying, using or removing dielectric fluids in electrical capacitors or electrical transformers containing a dioxin-like polychlorinated biphenyl;

(c)          applying, using or removing hydraulic fluids or heat transfer material containing a dioxin-like polychlorinated biphenyl;

(d)          applying, using or removing insulation material, electrical cable, ventilation gaskets, soundproofing material, missile launch tubes, banding and sheet rubber, surface coatings or steel containing a dioxin-like polychlorinated biphenyl;

(e)          applying, using or removing metal coatings (such as on the hulls of ships) or heat resistant paint containing a dioxin-like polychlorinated biphenyl;

(f)           applying, using or removing sealants containing a dioxin-like polychlorinated biphenyl;

(g)          living in an area heavily polluted with a dioxin-like polychlorinated biphenyl due to waste incineration of materials or fires containing a dioxin-like polychlorinated biphenyl;

(h)          shovelling or sweeping of debris contaminated with a dioxin-like polychlorinated biphenyl;

(i)            working in the dismantling of ships, submarines or other structures containing a dioxin-like polychlorinated biphenyl;

(j)            working in the recycling of electronic equipment containing a dioxin-like polychlorinated biphenyl; or

(k)          undertaking work involving incineration of waste materials or fires containing a dioxin-like polychlorinated biphenyl.

                               MET means a unit of measurement of the level of physical exertion. 1 MET = 3.5 ml of oxygen/kg of body weight per minute, 1.0 kcal/kg of body weight per hour, or resting metabolic rate.

                               MRCA means the Military Rehabilitation and Compensation Act 2004.

                               paraganglioma means a neoplasm of chromaffin tissue which is associated with excess secretion of catecholamines, and is located in an extra-adrenal sympathetic ganglion.

                               phaeochromocytoma means a neoplasm of chromaffin tissue which is associated with excess secretion of catecholamines, and is located in the adrenal medulla. 

                               primary hyperaldosteronism means a syndrome associated with excess production of the major adrenal mineralocorticoid, aldosterone.

                               relevant service means:

(a)          operational service under the VEA;

(b)          peacekeeping service under the VEA;

(c)          hazardous service under the VEA;

(d)          British nuclear test defence service under the VEA;

(e)          warlike service under the MRCA; or

(f)           non-warlike service under the MRCA.

Note: MRCA and VEA are also defined in the Schedule 1 - Dictionary.

                               Specified List 1 of drugs means:

(a)          alkylating agents including cyclophosphamide;

(b)          bromocriptine mesylate;

(c)          cisplatin;

(d)          cyclosporine A;

(e)          docetaxel;

(f)           erythropoietins including epoetin alfa, epoetin beta, darbepoetin alfa and methoxy polyethylene glycol-epoetin beta;

(g)          ibrutinib;

(h)          mammalian target of rapamycin inhibitors including sirolimus and everolimus;

(i)            monoamine oxidase inhibitors including phenelzine, tranylcypromine and selegiline;

(j)            physostigmine;

(k)          proteasome inhibitors including bortezomib and carfilzomib;

(l)            tacrolimus; or

(m)        vascular endothelial growth factor (VEGF) inhibitors.

Note: Vascular endothelial growth factor (VEGF) inhibitors include monoclonal antibodies, such as bevacizumab and ramucirumab; the fusion molecule aflibercept; and tyrosine kinase inhibitors, such as cabozantinib, sorafenib, sunitinib and vandetanib.

                               Specified List 2 of drugs means:

(a)          amprenavir;

(b)          atazanavir;

(c)          boceprevir;

(d)          clarithromycin;

(e)          darunavir;

(f)           delavirdine;

(g)          erythromycin;

(h)          fosamprenavir;

(i)            indinavir;

(j)            isoniazid;

(k)          itraconazole;

(l)            ketoconazole;

(m)        lopinavir;

(n)          nelfinavir;

(o)          posaconazole;

(p)          ritonavir;

(q)          saquinavir;

(r)           telaprevir;

(s)           telithromycin;

(t)            tipranavir; or

(u)          voriconazole.

                               specified list of endocrine disorders means:

(a)          a renin-secreting neoplasm;

(b)          acromegaly;

(c)          Cushing syndrome;

(d)          hyperparathyroidism;

(e)          hyperthyroidism, including goitre or Graves disease that has resulted in hyperthyroidism;

(f)           hypothyroidism, including Hashimoto thyroiditis that has resulted in hypothyroidism;

(g)          phaeochromocytoma or paraganglioma;

(h)          primary hyperaldosteronism; or

(i)            thyrotoxicosis.

Note: acromegaly, hyperparathyroidism, phaeochromocytoma, paraganglioma and primary hyperaldosteronism are also defined in the Schedule 1 - Dictionary.

                               terminal event means the proximate or ultimate cause of death and includes the following:

(a)           pneumonia;

(b)           respiratory failure;

(c)           cardiac arrest;

(d)           circulatory failure; or

(e)           cessation of brain function.

                               VEA means the Veterans' Entitlements Act 1986.

Schedule 2 - Drugs  

Note:               See Section 6, Subsections 9(14) and 9(39)

1               Specified Drugs

Note 1: Examples of nasal decongestants at Item 24 include oxymetazoline, phenylephrine, tramazoline and xylometazoline.

Note 2: Examples of oral decongestants at Item 24 include phenylephrine and pseudoephedrine.